Preheat your oven to 350°F (175°C).
In a mixing bowl, combine ground beef, garlic powder, onion powder, salt, and pepper.
Form the beef mixture into small patties, about 2 inches in diameter, to fit the slider buns.
Place the patties on a baking sheet lined with parchment paper or a greased baking dish.
Bake the patties in the preheated oven for 15-20 minutes, or until they reach your desired doneness.
During the last few minutes of baking, place a slice of cheese on each patty to melt.
Remove the patties from the oven and let them rest for a few minutes.
Assemble the sliders by placing each patty on a bun and topping with your favorite condiments and vegetables.