Preheat the Air Fryer to 375°F (190°C).
In a large bowl, combine ground beef, garlic powder, onion powder, smoked paprika, salt, black pepper, and Worcestershire sauce.
Divide the mixture into four equal portions and shape them into patties, about ¾-inch thick.
Place the patties in the air fryer basket, ensuring they do not overlap.
Cook for 10 minutes, flipping halfway through, until internal temperature reaches 160°F (71°C).
If adding cheese, place a slice on each patty during the last 1-2 minutes of cooking.
Remove the patties from the air fryer and let rest for 5 minutes before serving.
Assemble your burgers on buns with desired toppings and serve hot.